Ron Majors reviews Diamond Analytics' technology

Highlights of HPLC 2010

Some novel core-shell phases were developed by a group from Brigham Young University led by Matthew Linford. One approach used 1.7-μm zirconia cores with a 0.5-μm porous nanodiamond shell. After functionalizing with C18, the columns were used to separate aromatic analytes. The disadvantage of this approach was the high cost of the raw materials so the authors switched to a graphite core which was also coated with nanodiamonds but the peak shape was undesirable. However, pH stability was quite remarkable and further work on improving the phase chemistry could result in useful packing.

A number of comparison papers appeared again showing the superior performance of the SPP when compared to the totally porous sub-2-μm particles, especially when the pressure drop is taken into account. In addition, numerous applications of the SPP are beginning to appear and at HPLC 2010, separations of pharmaceuticals (antibiotics, pain management drugs, anti-inflammatory drugs and various others), aflatoxins, drugs of abuse, genotoxins, small proteins and peptides, melamine/cyanuric acid and food and beverage additives were noted. Also, applications of SPP for SFC and as the secondary dimension in LC×LC are showing up.

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