The key aspect of diamond-based columns is their ability to easily handle expanded pH ranges (1 to 13) during drug and protein separations. The robust nature of a diamond-based column allows it to be easily regenerated—unlike standard silica columns.
Proteins are complex structures that are essential in modern drug development and discovery. Proteins are vital building blocks in our bodies and play a major role in creating overall health and wellness. In laboratory settings, separating complex proteins from other chemical structures, impurities and excipients is a major challenge for the pharmaceutical industry. The problem is that proteins are extremely fragile and denature easily. In addition, these complex compounds are notorious for “sticking” onto columns, making their purification, analysis and quantitation difficult. But, new diamond-based, core-shell HPLC columns hold more potential.
“We’re finding that diamond-based columns are ideally suited for difficult separations,” says Andrew Dadson, general manager at Diamond Analytics. “As customers search for easier and more effective ways to separate complex compounds, nano-diamond columns provide a more robust solution that delivers better resolution and peak shape in certain challenging separations.”
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